Shida (Steven) Qiao
一个定量行业从业者
偶尔骑一下自行车
PMx
Pharmacokinetics
Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism.
Drug metabolism and pharmacokinetics (DMPK) is a core discipline in drug development that considers the biotransformation of a drug compound and other pharmacokinetic properties to assess drug safety.
PK/PD modeling (pharmacokinetic/pharmacodynamic modeling) (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics. It integrates a pharmacokinetic and a pharmacodynamic model component into one set of mathematical expressions that allows the description of the time course of effect intensity in response to administration of a drug dose. PK/PD modeling is related to the field of pharmacometrics.
Pharmacometrics
Pharmacometrics uses mathematical models of biology, pharmacology, disease, and physiology to describe and quantify beneficial or adversary interactions between drugs and humans.
Pharmacometrics uses models to describe the beneficial and adverse effects of a drug therapy on a patient. Data extracted from pre-clinical studies, clinical studies, scientific literature and competitor regulatory filings are integrated, building a complete data package describing the characteristics of a given lead compound. From this integrated data set, mathematical models of exposure and response are built and qualified. These models become a representation of what is known about the compound’s behavior.
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一些其他应该知道的内容
定量药理的工具
xgx
探索性分析工具
NLMIXR
nlmixr is a free and open-source R package for fitting nonlinear pharmacokinetic (PK), pharmacodynamic (PD), joint PK-PD, and quantitative systems pharmacology mixed-effects models.
ggPMX
为MONOLIX,NONMEM设计的基于ggplot2的定量药理绘图包
Pumas
基于Julia的，定量药理建模软件。
Python
基于Python的群体药代动力学建模软件。
Matlab
SimBiology,PBPK和semi-mechanism建模软件。
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